Lesson 10 of 12

Negative controls and evidence grades

Before trusting a result, we run the same test on records that should show nothing. Then the grades compress what the evidence supports, not what anyone hopes.

The answer first

A negative control is a placebo test for a method: run the identical pipeline on random records that have no reason to carry skill, and see what it finds. If the placebo run finds as much as the real run, the method is measuring noise. The grades (A/B/C/D) then fold each wallet's evidence into one letter with frozen, quoted gates, so a reader can triage a cohort without re-deriving the statistics.

The intuition, with one worked example

Suppose a client hands us 40 wallets and asks which show skill. The pipeline says 3 survive the corrected test. Is 3 impressive? On its own, unanswerable. So we draw 500 random cohorts of 40 wallets each from outside the client's list, size-matched, and push every one through the identical pipeline. If only a few percent of random cohorts produce 3 or more survivors, the client's list beats chance. If a third of random cohorts do, the honest report says the list looks like chance, however the list was assembled. This matters because wallet lists are usually assembled from winners someone noticed, and noticing winners is itself a luck-harvesting filter.

The actual method

The negative control: 500seeded, size-matched placebo cohorts, drawn without replacement per draw from wallets outside the set under review, run through the identical false-discovery pipeline. The report states the empirical probability that chance matches or beats the real cohort's survivor count, and it stays prominent in the deliverable. The seeding makes the draws reproducible.

The grade legend, quoted from the frozen specification:

  • A, Strong

    "Skilled read that survives correction at q=0.05 on a complete, diversified record with a tight interval."

  • B, Moderate

    "Skilled read with one weakness: survives only at q=0.10, or capped coverage, or high single-event share, or a wide interval."

  • C, Weak

    "A concentration-flagged or not-separable-from-chance read, or a skilled read with two or more weaknesses."

  • D, Insufficient

    "Too few resolved positions to read an edge either way; no record evidence to grade."

Grade A specifically requires survival at q = 0.05 with no coverage cap on the record, a diversified book, and an interval no wider than 12 probability points. Each graded wallet also carries one binding caveat naming its largest structural weakness (capped coverage, one event driven, or single-category dependence), or none.

Where you see this on the site

Both live in the enterprise cohort audit deliverable, delivered per period with the survivor counts, the negative-control baseline, and the grade column side by side. The concepts have their own glossary pages at /learn/negative-control and /enterprise describes the engagement itself.

What this does NOT mean

A grade is not a rating of a person and not a forecast; it compresses the strength of the resolved record evidence, nothing more. D is not an insult: it says the record is too thin to grade either way. A null cohort result, where nobody clears and the placebo band explains everything, is a valid, reportable deliverable, not a failed engagement. And the negative control does not certify a method as correct; it only shows whether this result, on this cohort, beats what chance produces on same-sized random lists.

Convexly publishes new methodology research roughly every 6-8 weeks plus the /learn series on a rolling cadence. Get the next paper in your inbox when it ships:

Frequently asked

What is a negative control in a wallet cohort audit?

A placebo run: 500 size-matched cohorts of wallets drawn at random from outside the set under review, pushed through the identical statistical pipeline. If random cohorts produce as many survivors as the real cohort, the apparent result is what chance looks like, and the report says so plainly. The draws are seeded, so anyone re-running the pipeline gets the same placebo cohorts.

What do the A/B/C/D grades mean?

They compress the strength of the record evidence per wallet, with frozen gates. A (Strong) is a skilled read surviving correction at q=0.05 on a complete, diversified record with a tight interval. B (Moderate) is a skilled read with exactly one weakness. C (Weak) is a flagged or not-separable-from-chance read, or a skilled read with two or more weaknesses. D (Insufficient) means too few resolved positions to read an edge either way.

Why run placebo cohorts at all?

Because how a wallet list was picked can manufacture a result. A list assembled from wallets someone noticed because they won is pre-filtered for luck, and it will look better than random even if nobody in it has skill. The negative control anchors every cohort finding to what chance produces on same-sized random lists, which is the only fair baseline.

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